ABSTRACT
A simple, rapid and sensitive spectrophotometric procedure is described for the determination of cimetidine either in pure form or in pharmaceutical formulations. The method is based on the reaction of cimetidine as an electron donor with chloranilic acid as a pie electron acceptor. The charge transfer complex formed has a purple colour with a maximum absorbance at about 530 nm. The calibration graph was linear over the range of 25-200 [micro] g/ml. The method was applied to cimetidine in pharmaceutical formulations giving accurate, precise and reproducible results. Comparing these results with those obtained using the British Pharmacopeal method, and with one of the compendial colourimetric methods, there is no significant difference between the performance of the three methods using the Student's t-test and the variance ratio F-test. In addition the proposed method is more simple and rapid